Highlighted Publication

Tryptophan-Kynurenine Pathway Activation and Cognition in Virally Suppressed Women With HIV

2024 JAIDS Journal of Acquired Immune Deficiency Syndromes article

Shorer, Eran Frank, Dastgheyb, Raha M, French, Audrey L, Daubert, Elizabeth, Morack, Ralph, Yohannes, Tsion, Clish, Clary, Gustafson, Deborah, and 3 others

Figure from Tryptophan-Kynurenine Pathway Activation and Cognition in Virally Suppressed Women With HIV
DOI
Why This Matters

The tryptophan-kynurenine pathway is a biologically plausible link between immune activation, metabolism, and cognition. This paper is highlighted because it brings a targeted biomarker pathway into the cognitive-health program for virally suppressed women with HIV. Since the local source contains only limited metadata, the current narrative avoids overclaiming specific results until the PDF or complete abstract is available.

Key Findings
  • The paper focuses on tryptophan-kynurenine pathway activation in virally suppressed women with HIV.
  • It connects metabolomic or immune-metabolic biomarkers to cognitive outcomes.
  • The study extends the broader women-with-HIV cognitive phenotyping program into a mechanistic biomarker domain.
  • A full local PDF or abstract is needed before adding pathway-specific results, cognitive-domain findings, or effect estimates.
Plain-Language Summary

This paper examines whether activity in the tryptophan-kynurenine pathway, a metabolic pathway tied to inflammation and immune signaling, is related to cognition among virally suppressed women with HIV. The page is currently conservative because the local source file does not yet include the complete abstract or paper text.