Research Thread

Biomarker Systems

Linking molecular, imaging, and cognitive signals through reproducible analytic systems.

Illustration of biomarker analytics connecting blood samples, molecular signals, instrumentation, and computational networks.

This thread connects multi-omics, neuroimaging, inflammatory markers, and cognitive outcomes. It emphasizes pipelines that make biomarker discovery interpretable, reproducible, and useful across interdisciplinary teams.

Scientific Question

Which biological signals help explain cognitive decline, mental health changes, and brain health trajectories?

Connected Publications
Figure from Tryptophan-Kynurenine Pathway Activation and Cognition in Virally Suppressed Women With HIV
2024 article highlighted

Tryptophan-Kynurenine Pathway Activation and Cognition in Virally Suppressed Women With HIV

Eran Frank Shorer, Raha M. Dastgheyb, Audrey L. French, Elizabeth Daubert, Ralph Morack, Tsion Yohannes, Clary Clish, Deborah Gustafson, Anjali Sharma, Andre Rogando, Qibin Qi, Helen Burgess, Leah H. Rubin, Kathleen M. Weber

JAIDS Journal of Acquired Immune Deficiency Syndromes

Studies whether tryptophan-kynurenine pathway activation is associated with cognition in virally suppressed women with HIV.

Figure from Metabolomic levels mediate the link between socioeconomic factors and changes in declarative memory in women with and without HIV
2026 article highlighted

Metabolomic levels mediate the link between socioeconomic factors and changes in declarative memory in women with and without HIV

César Higgins Tejera, Raha Dastgheyb, Eran F. Shorer, Susie Lee, Deborah Gustafson, Anjali Sharma, Gypsyamber D'Souza, Kathleen M. Weber, Qibin Qi, Leah H. Rubin, Kathryn C. Fitzgerald

Brain, Behavior, & Immunity-Health

Links socioeconomic conditions, metabolomic profiles, and longitudinal declarative memory change in women with and without HIV.

Figure from Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study
2025 article highlighted

Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study

Leah H. Rubin, Wen Shi, Alba Azola, Aparna Bhattacharyya, Raha M. Dastgheyb, Jiani Wu, Christina Della Penna, Hannah Parker, Isabel Santiuste, Ana Ehrenspeck, Jennifer M. Coughlin, Tracy D. Vannorsdall, Hanzhang Lu, Rebecca Veenhuis

Brain, Behavior, and Immunity

Uses non-contrast MRI to study blood-brain barrier permeability and cognition in Long COVID.

Figure from Plasma neurofilament light chain and glial fibrillary acidic protein as biomarkers of cognitive decline in people with human immunodeficiency virus
2025 article selected

Plasma neurofilament light chain and glial fibrillary acidic protein as biomarkers of cognitive decline in people with human immunodeficiency virus

Shibani S. Mukerji, Petra Bachanová, Hemi Park, Linzy V. Rosen, Rommi Kashlan, Pia Kivisäkk, Albert M. Anderson, Felicia C. Chow, Kunling Wu, Raha M. Dastgheyb, Leah H. Rubin, Katherine Tassiopoulos, Robert A. Parker, Emily P. Hyle

The Journal of Infectious Diseases

This paper helps define a research thread in translational brain health research, providing context for how computational and translational evidence can be organized into reusable scientific systems.

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