Research Thread
Cellular Systems & Axonal Injury
Biomedical engineering foundations in traumatic brain injury, axonal pathology, electrophysiology, and neural systems.
This thread preserves the engineering and cellular neuroscience foundation of the research program. Work on axonal pathology, traumatic brain injury, extracellular vesicles, astrocyte-neuron signaling, and high-throughput electrophysiology helped shape the later emphasis on scientific software and translational data systems.
How did engineering approaches to axonal injury, extracellular vesicles, and neural network activity shape the later software-first brain health program?
Mechanisms of axonal pathology in the context of traumatic brain injury
Drexel University
Traumatic Brain Injury (TBI) affects approximately 270,000 people a year and costs the U.S. more than $48 billion annually. Around 70,000 people die each year from head injuries, but many of …
Quantifying focal disruptions in axonal microtubules
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)
Quantification of beading intensity in cultured neurons
2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC)
Role of human-induced pluripotent stem cell-derived spinal cord astrocytes in the functional maturation of motor neurons in a multielectrode array system
Stem Cells Translational Medicine
The ability to generate human-induced pluripotent stem cell (hiPSC)-derived neural cells displaying region-specific phenotypes is of particular interest for modeling central nervous system …
Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS
Proceedings of the National Academy of Sciences