Research Thread

Long COVID & Brain Health

Connecting cognitive outcomes, biomarkers, and clinical data streams in post-acute brain health.

This thread follows the translational data science needed to understand cognitive and brain health outcomes in Long COVID, including biomarker integration, clinical measurement, and collaborative cohort analytics.

Scientific Question

How do vascular, inflammatory, behavioral, and cognitive measurements fit together in Long COVID?

Software
Biomarker Analytics Systems Computational systems for connecting biomarker data to brain health outcomes. Scientific Reporting Frameworks Reproducible reporting systems that turn analysis workflows into publication-ready scientific outputs.
Research Areas
Biomarker Systems Analytical systems for connecting biomarker signals to translational brain health questions. Translational Neuroinformatics Computational infrastructure linking cohorts, biomarkers, cognition, and brain health outcomes.
Connected Publications
Figure from Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study
2025 article highlighted

Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study

Leah H. Rubin, Wen Shi, Alba Azola, Aparna Bhattacharyya, Raha M. Dastgheyb, Jiani Wu, Christina Della Penna, Hannah Parker, Isabel Santiuste, Ana Ehrenspeck, Jennifer M. Coughlin, Tracy D. Vannorsdall, Hanzhang Lu, Rebecca Veenhuis

Brain, Behavior, and Immunity

Uses non-contrast MRI to study blood-brain barrier permeability and cognition in Long COVID.

Figure from Cognitive sequala of loneliness in long COVID: Differential associations by loneliness subtypes
2026 article archive

Cognitive sequala of loneliness in long COVID: Differential associations by loneliness subtypes

Leah H. Rubin, Alba Azola, Moka Yoo-Jeong, Raha M. Dastgheyb, Rebecca Easter, Ana Ehrenspeck, Jennifer M. Coughlin, Tracy D. Vannorsdall, Rebecca Veenhuis, Tracey Wilson

Journal of Affective Disorders

This paper helps define a research thread in translational analysis of Long COVID and cognitive outcomes, providing context for how computational and translational evidence can be organized into reusable scientific systems.

Figure from Putting the PASC Score to the Test: Clinical vs. Statistical Accuracy in Long COVID Diagnosis: Azola et al.
2025 article archive

Putting the PASC Score to the Test: Clinical vs. Statistical Accuracy in Long COVID Diagnosis: Azola et al.

Alba Azola, Raha M. Dastgheyb, Rebecca Easter, Hannah Parker, Christina Della Penna, Isabel Santiuste, Holly Schultz, Ana Ehrenspeck, Rebecca Veenhuis, Leah H. Rubin

Journal of general internal medicine

This paper helps define a research thread in translational analysis of Long COVID and cognitive outcomes, providing context for how computational and translational evidence can be organized into reusable scientific systems.

Related Talks

Biomedical Data Science for Brain Health

From patient cohorts to cellular circuits through reproducible computational systems.

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