Research Thread

Organoid Intelligence

Field-building around organoid intelligence, neural systems, and responsible scientific infrastructure.

This thread connects cellular systems, emerging brain-inspired technologies, high-throughput electrophysiology, and the community infrastructure needed for a new scientific field.

Scientific Question

What shared technical and ethical infrastructure is needed for a new brain-inspired research field?

Software
MEAnalyzer Published, citable, downloadable MATLAB software for multi-electrode array data analysis.
Research Areas
Software Systems Scientific software as scholarship, infrastructure, and translational method. Scientific Visualization Visual systems for making complex analyses interpretable, inspectable, and useful.
Connected Publications
Figure from The Baltimore declaration toward the exploration of organoid intelligence
2023 article highlighted

The Baltimore declaration toward the exploration of organoid intelligence

Thomas Hartung, Lena Smirnova, Itzy E. Morales Pantoja, Akwasi Akwaboah, Dowlette-Mary Alam El Din, Cynthia A. Berlinicke, J. Lomax Boyd, Brian S. Caffo, Ben Cappiello, Tzahi Cohen-Karni, J. Lowry Curley, Ralph Etienne-Cummings, Raha Dastgheyb, David H. Gracias, Frederic Gilbert, Christa Whelan Habela, Fang Han, Timothy D. Harris, Kathrin Herrmann, Eric J. Hill, Qi Huang, Rabih E. Jabbour, Erik C. Johnson, Brett J. Kagan, Caroline Krall, Andre Levchenko, Paul Locke, Alexandra Maertens, Monica Metea, Alysson R. Muotri, Rheinallt Parri, Barton L. Paulhamus, Jesse D. Plotkin, Paul Roach, July Carolina Romero, Jens C. Schwamborn, Fenna Sillé, Alexander S. Szalay, Katya Tsaioun, Daniel Tornero, Joshua T. Vogelstein, Karl J. Wahlin, Donald J. Zack

Frontiers in Science

Defines organoid intelligence as an emerging discipline requiring technical, ethical, and community infrastructure.

Figure from First Organoid Intelligence (OI) workshop to form an OI community
2023 article archive

First Organoid Intelligence (OI) workshop to form an OI community

Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung

Frontiers in artificial intelligence

This paper helps define a research thread in community standards and scientific infrastructure for organoid intelligence, providing context for how computational and translational evidence can be organized into reusable scientific systems.

Figure from Altered development and network connectivity in a human neuronal model of 15q11. 2 deletion-related neurodevelopmental disorders
2025 article archive

Altered development and network connectivity in a human neuronal model of 15q11. 2 deletion-related neurodevelopmental disorders

Christa W. Habela, Shiyu Liu, Arens Taga, Sean Oddoye, Raha Dastgheyb, Norman Haughey, Dwight E. Bergles, Hongjun Song, Guo-Li Ming, Nicholas J. Maragakis

Translational psychiatry

This paper helps define a research thread in translational brain health research, providing context for how computational and translational evidence can be organized into reusable scientific systems.

Related Talks

Biomedical Data Science for Brain Health

From patient cohorts to cellular circuits through reproducible computational systems.

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